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Preparation and Diuretic Properties of Novel Amiloride Analogues
Author(s) -
Russ Thomas,
Ried Walter,
Ullrich Frank,
Mutschler Ernst
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923251204
Subject(s) - amiloride , triamterene , diuretic , chemistry , hydrochlorothiazide , pharmacology , sodium , endocrinology , medicine , organic chemistry , blood pressure
Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6‐substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2‐position were found equal or better than standards. The results are discussed with respect to chemical structure and physicochemical properties.