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Removal of the Pyrrolidine Group by Dehydrogenation of a 4‐Pyrrolidin‐2‐yl‐tetrahydroisoquinoline
Author(s) -
Mahboobi Siavosh,
Seidl Engelbert,
Wiegrebe Wolfgang
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923251011
Subject(s) - dehydrogenation , pyrrolidine , tetrahydroisoquinoline , chemistry , group (periodic table) , functional group , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , polymer
Dehydrogenation of 6,7‐dimethoxy‐1‐methyl‐4‐( N ‐methyl‐pyrrolidin‐2‐yl)‐3,4‐dihydroisoquinoline ( 9 ) by Pd/C in tetraline leads to dehydrogenated products, rearrangement, and elimination of the pyrrolidine group mainly as N ‐methylpyrrolidine (Scheme 3).
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