Synthesis of Biologically Active [2.2]Paracyclophanes | Zendy

Aly Ashraf A. | Zendy; Hassan Alaa A. | Zendy; Mourad AboulFetouh E. | Zendy; Hopf Henning | Zendy

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Synthesis of Biologically Active [2.2]Paracyclophanes

Author(s) -

Aly Ashraf A.,

Hassan Alaa A.,

Mourad AboulFetouh E.,

Hopf Henning

Publication year - 1992

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19923251002

Subject(s) - chemistry , benzylamine , mannich reaction , biological activity , paraformaldehyde , derivative (finance) , organic chemistry , claisen condensation , catalysis , in vitro , biochemistry , economics , financial economics

Claisen reaction of 4‐acetyl[2.2]paracyclophane ( 1 ) with ethyl acetate and diethyl oxalate affords 4‐acetoacetyl[2.2]paracyclophane ( 2 ) and ethyl(4‐oxaloacetyl[2.2]paracyclophane) ( 6 ), respectively. Reaction of 2 and 6 with hydrazines and CuCl 2 gave the pyrazole derivatives 4 and 8 in addition to the metal complexes 5 and 9 . Mannich reaction of 2 with benzylamine and paraformaldehyde yielded the piperidinone derivative 3 . The biological activity of all new compounds was tested.

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