Biotransformation of the Sympathomimetic Tetraminol  in vitro | Zendy

Drandarov Konstantin | Zendy; Kvasničková Eva | Zendy; Hais I. M. | Zendy

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Biotransformation of the Sympathomimetic Tetraminol in vitro

Author(s) -

Drandarov Konstantin,

Kvasničková Eva,

Hais I. M.

Publication year - 1992

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19923250912

Subject(s) - metabolite , biotransformation , demethylation , chemistry , incubation , in vitro , guinea pig , pharmacology , active metabolite , endocrinology , medicine , biochemistry , biology , enzyme , gene expression , dna methylation , gene

On incubation with the postmitochondrial fraction of the liver homogenate of rabbits, guinea‐pigs, rats, and mice in the presence of NADPH and oxygen, the α‐sympathomimetic trans ‐3‐(2‐hydroxyethylamino)‐5,8‐dimethoxy‐1,2,3,4‐tetrahydro‐2‐naphthol (Tetraminol, 1 ) is preferentially O ‐demethylated in position 8, yielding metabolite 3. In male rats O ‐demethylation is stronger than in females.

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