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Biotransformation of the Sympathomimetic Tetraminol in vitro
Author(s) -
Drandarov Konstantin,
Kvasničková Eva,
Hais I. M.
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250912
Subject(s) - metabolite , biotransformation , demethylation , chemistry , incubation , in vitro , guinea pig , pharmacology , active metabolite , endocrinology , medicine , biochemistry , biology , enzyme , gene expression , dna methylation , gene
On incubation with the postmitochondrial fraction of the liver homogenate of rabbits, guinea‐pigs, rats, and mice in the presence of NADPH and oxygen, the α‐sympathomimetic trans ‐3‐(2‐hydroxyethylamino)‐5,8‐dimethoxy‐1,2,3,4‐tetrahydro‐2‐naphthol (Tetraminol, 1 ) is preferentially O ‐demethylated in position 8, yielding metabolite 3. In male rats O ‐demethylation is stronger than in females.