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Pyrrylphenylethanones Related to Cathinone and Lefetamine: Synthesis and Pharmacological Activities
Author(s) -
Massa Silvio,
Santo Roberto Di,
Mai Antonello,
Artico Marino,
Carlo Pantaleoni Gian,
Giorgi Raffaele,
Francesca Coppolino Maria
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250707
Subject(s) - cathinone , chemistry , stereochemistry , morphine , biological activity , action (physics) , pharmacology , biochemistry , medicine , in vitro , physics , amphetamine , quantum mechanics , dopamine
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2‐chloro‐1‐(1‐methyl‐1 H ‐pyrrol‐2‐yl)‐2‐phenylethan‐1‐one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.