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Synthesis and Antimicrobial Activity of 3‐(Substituted‐phenyl)‐sydnones
Author(s) -
Moustafa M. A. A.,
Eisa H. M.
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250706
Subject(s) - sydnone , chalcone , acetic anhydride , chemistry , antimicrobial , organic chemistry , condensation reaction , nitrosation , combinatorial chemistry , catalysis , ring (chemistry)
3‐(3 or 4‐Acetylphenyl)‐sydnones 7, 8 have been synthesized by formation of the glycines 3, 4 , followed by nitrosation to 5, 6 and cyclization with acetic anhydride to sydnones. Sydnone derivatives carrying chalcone moieties 15, 16 were prepared by formation of the chalcone analogues 11, 12 through condensation of the glycines 3, 4 with the appropriate aldehydes, followed by the reactions applied for the preparation of 7, 8 . The sydnone derivatives were screened for antimicrobial activities.