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Nitroimidazoles, XIV : Synthesis of 4‐Nitroimidazoles with 1‐Substituents Containing Acid, Ester or Phenol Functions, and Radiosensitizing Efficiency of Some of These Compounds
Author(s) -
Suwinski Jerzy,
Szczepankiewicz Wojciech,
Widel Maria
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250602
Subject(s) - chemistry , phenol , nitro compound , nitro , organic chemistry , chemical synthesis , biochemistry , in vitro , alkyl
1, 4‐Dinitroimidazole and 1, 4‐dinitro‐2‐methylimidazole were reacted with aminocarboxylic acids and their esters, aminosulfonic acids, and aminophenol to obtain the corresponding 1‐substituted‐4‐nitroimidazoles. The radiosensitizing efficiency of some esters of 2‐(4‐nitro‐1‐imidazolyl)alkanecarboxylic acids was tested.