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On the Conformation of 1‐Aryl‐1,4‐dihydro‐3(2 H )‐isoquinolinones
Author(s) -
Mokrosz Jerzy L.,
Cegla Marek T.,
Szneler Edward
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250409
Subject(s) - aryl , chemistry , ring (chemistry) , stereochemistry , organic chemistry , alkyl
1 H‐ and 13 C‐NMR spectra of the 1‐aryl‐1,4‐dihydro‐3(2 H )‐isoquinolinones 2a‐1 were examined. It was found that the 1‐aryl group assumes a roughly axial position on the boat conformation of the heterocyclic ring in meta ‐ and para ‐substituted derivatives only. However, the ortho ‐substituted 1‐phenyl group occupies the quasi equatorial position.