Premium
Platelet Aggregation Inhibiting and Anticoagulant Effects of Oligoamines, XW: Oligoamines with Fluorescent Properties Part A: Fluorescent Bridged Nitrogen Functions
Author(s) -
Rehse K.,
Seidel T.
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250408
Subject(s) - fluorescence , platelet aggregation , chemistry , anticoagulant , biophysics , platelet , medicine , biology , physics , quantum mechanics
Eleven dimethanamines and one disydnonimine with fluorescent properties have been synthesized. All of them show antiplatelet activities (IC 50 , Born ‐test) in concentrations between 14–75 μmol/L. Five of them inhibited fibrin formation induced by thromboplastin by more than 75% in a 200 μmolar concentration. Both effect do not run parallel. The most space consuming fluorophores show the smallest inhibition of the platelet aggregation. Best results were obtained with an azulene, acenaphthene or naphthalene moiety between the two basic nitrogen functions.