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Researches on Antibacterial and Antifungal Agents, XIV: Thiophene Analogues of Bifonazole
Author(s) -
Stefancich Giorgio,
Silvestri Romano,
Retico Augusta,
Artico Marco,
Simonetti Giovanna
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250403
Subject(s) - bifonazole , antifungal , thiophene , chemistry , combinatorial chemistry , antibacterial activity , organic chemistry , microbiology and biotechnology , bacteria , biology , genetics
Some thiophene analogues of bifonazole have been synthesized by standard procedures and their antifungal activity has been tested against Candida albicans. Among test derivatives biphenyl‐4‐yl‐5‐chloro‐thien‐2‐ylimidazol‐1‐ylmethane and its 5‐deschlorothien‐2‐yl analogue resulted to be the most active. Their antifungal potency was almost comparable to that of control substances, such as miconazole, ketoconazole, and bifonazole. Replacement of benzene by the pyrrole ring in the biphenyl portion retained almost quantitatively the antifungal activity, whereas substitution with other azoles and with nitrogen alicyclic rings led always to less potent derivatives.