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Pyridazines, LVII: Synthesis and Cyclocondensation Reactions of (2‐Aminophenyl)‐(4‐pyridazinyl)‐ketone, a New Diaza Isoster of 2‐Aminobenzophenone
Author(s) -
Haider Norbert,
Heinisch Gottfried,
Moshuber Jöran
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250212
Subject(s) - chemistry , intramolecular force , ketone , quinazoline , amide , derivative (finance) , condensation reaction , medicinal chemistry , condensation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , physics , financial economics , economics , thermodynamics
A convenient approach to the new 2‐aminobenzophenone analogue 4 is reported. Condensation reactions of 4 with ortho esters or amide acetals, respectively, followed by intramolecular cyclisations were found to provide smooth access to (4‐pyridazinyl)‐substituted quinolines 10, 13a,b , and the quinazoline derivative 15 .