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Evaluation of the Mammary Tumor Inhibiting Properties
Author(s) -
Schertl Sabine,
Gust Ronald,
Müller Richard,
Spruß Thilo,
Schönenberger Helmut
Publication year - 1992
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19923250211
Subject(s) - chemistry , pharmacology , cancer research , biology
Stereoisomeric [1,2‐bis(3‐hydroxyphenyl)ethylenediamine]platinum(II) complexes produce a strong configuration dependent inhibition of the hormone sensitive MXT‐mammary carcinoma of the mouse. Besides an interference in the DNA synthesis in analogy to cisplatin an estrogen level lowering effect is supposed to be the mode of action. The new complexes show also a significant activity on the hormone‐independent MXT‐mammary carcinoma of the mouse.