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Synthesis and Hypolipidemic Activity of Amine‐Carboxyboranes, and Their Amides and Esters in Rodents
Author(s) -
Sood Anup,
Sood Cynthia K.,
Spielvogel Bernard F.,
Hall Iris H.,
Wong Oi T.,
Mittakanti Mallaiah,
Morse Karen
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240705
Subject(s) - chemistry , methylamine , ethylamine , trimethylamine , biochemistry , cholesterol , metabolism , enzyme , organic chemistry
A series of amine carboxyboranes including their amides and esters were synthesized and shown to have potent hypolipidemic activity in rodents at 20 mg/kg/day. Ethylamine carboxyborane, di‐ n ‐propylamine‐carboxyborane, trimethylamine‐carbomethoxyborane, n ‐butylamine carbomethoxyborane, methylamine‐ N ‐ethyl carbamoylborane and trimethylamine‐ N ‐ n ‐octyl carbamoylborane were the most potent derivatives demonstrating hypocholesterolemic and hypotriglycemic activities in rats orally at 20 mg/kg/day. These derivatives lowered tissue lipids, e.g. cholesterol, in the rat liver, small intestine and aorta. The fecal lipids were elevated. Furthermore, the agents lowered cholesterol and triglycerides in the serum VLDL and LDL fractions but caused elevations in the HDL fraction after 14 days. The agents inhibited hepatic enzymatic activities of rate limiting steps involved in lipid metabolism, e.g. ATP dependent citrate lyase, sn ‐glycerol‐3‐phosphate acyltransferase and phosphatidylate phosphohydrolase.