Tumor Inhibiting [1,2‐Bis(fluorophenyl)ethylenediamine]platinum(II) Complexes . Part IV: Biological Evaluation ‐  in vivo  Studies on the P 388 Leukemia | Zendy

Reile Herta | Zendy; Spruß Thilo | Zendy; Bernhardt Günther | Zendy; Müller Richard | Zendy; Gust Ronald | Zendy; Schönenberger Helmut | Zendy

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Tumor Inhibiting [1,2‐Bis(fluorophenyl)ethylenediamine]platinum(II) Complexes . Part IV: Biological Evaluation ‐ in vivo Studies on the P 388 Leukemia

Author(s) -

Reile Herta,

Spruß Thilo,

Bernhardt Günther,

Müller Richard,

Gust Ronald,

Schönenberger Helmut

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19913240702

Subject(s) - ethylenediamine , chemistry , platinum , in vivo , stereochemistry , in vitro , medicinal chemistry , biological activity , leukemia , biochemistry , organic chemistry , medicine , catalysis , biology , microbiology and biotechnology

In experiments on the P 388 leukemia of the mouse diaqua‐[1,2‐bis‐(fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates show a strong antitumor activity irrespective of the position of the fluorine atom (ortho, meta or para) and of their configuration (R.R/S.S or R,S).

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