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Tumor Inhibiting [1,2‐Bis(fluorophenyl)ethylenediamine]platinum(II) Complexes . Part IV: Biological Evaluation ‐ in vivo Studies on the P 388 Leukemia
Author(s) -
Reile Herta,
Spruß Thilo,
Bernhardt Günther,
Müller Richard,
Gust Ronald,
Schönenberger Helmut
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240702
Subject(s) - ethylenediamine , chemistry , platinum , in vivo , stereochemistry , in vitro , medicinal chemistry , biological activity , leukemia , biochemistry , organic chemistry , medicine , catalysis , biology , microbiology and biotechnology
In experiments on the P 388 leukemia of the mouse diaqua‐[1,2‐bis‐(fluorophenyl)ethylenediamine]platinum(II) sulfates and nitrates show a strong antitumor activity irrespective of the position of the fluorine atom (ortho, meta or para) and of their configuration (R.R/S.S or R,S).