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Synthesis of New Benzimidazole Derivatives as Potential Antimicrobial Agents
Author(s) -
Badawey ElSayed A. M.,
Hassan Ahmed M. M.,
Kappe Thomas
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240607
Subject(s) - benzimidazole , thiourea , chemistry , antimicrobial , urea , isocyanate , bicyclic molecule , combinatorial chemistry , chemical synthesis , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , polyurethane , in vitro
Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N ′‐disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b . On the other hand, reaction of 1a with ethoxycarbonyl isocyanate ( 4 ) yielded the substituted s ‐triazine‐2,4,6(1 H ,3 H ,5 H )‐trione 5 . The reaction of 4 with 2‐aminomethyl‐benzimidazole ( 6 ) gave the allophanate 7 which upon treatment with Na 2 CO 3 yielded N ‐(1 H ‐benzimidazol‐2‐yl)urea 8 .