Synthesis of New Benzimidazole Derivatives as Potential Antimicrobial Agents | Zendy

Badawey ElSayed A. M. | Zendy; Hassan Ahmed M. M. | Zendy; Kappe Thomas | Zendy

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Synthesis of New Benzimidazole Derivatives as Potential Antimicrobial Agents

Author(s) -

Badawey ElSayed A. M.,

Hassan Ahmed M. M.,

Kappe Thomas

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19913240607

Subject(s) - benzimidazole , thiourea , chemistry , antimicrobial , urea , isocyanate , bicyclic molecule , combinatorial chemistry , chemical synthesis , medicinal chemistry , organic chemistry , stereochemistry , biochemistry , polyurethane , in vitro

Barbiturates 3 as possible antimicrobial agents were obtained by reacting the N,N ′‐disubstituted urea 1a or the thiourea analogues 1b,c with the magic malonates 2a,b . On the other hand, reaction of 1a with ethoxycarbonyl isocyanate ( 4 ) yielded the substituted s ‐triazine‐2,4,6(1 H ,3 H ,5 H )‐trione 5 . The reaction of 4 with 2‐aminomethyl‐benzimidazole ( 6 ) gave the allophanate 7 which upon treatment with Na 2 CO 3 yielded N ‐(1 H ‐benzimidazol‐2‐yl)urea 8 .

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