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Bestimmung von Metoprololtartrat durch Ionenpaarextraktion mit Bromthymolblau
Author(s) -
Ersoy Lale,
Kocaman Serpil
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240415
Subject(s) - chemistry , metoprolol tartrate , metoprolol , bromothymol blue , chromatography , extraction (chemistry) , salt (chemistry) , polarography , potentiometric titration , ion , organic chemistry , inorganic chemistry , anesthesia , medicine
Metoprolol, [4‐(2‐methoxyethyl)phenoxy]‐3‐[(1‐methylethyl)‐amino]‐2‐propanol, is a cardioselective adrenergic blocking agent used as metoprolol tartrate (2:1) salt in the treatment of hypertension, angina pectoris, and cardiac arrythmias. Although a number of analytical methods, e.g. high pressure liquid chromatography 1—4) , gas chromatography 5—7) and polarography 8) are used to determine the metoprolol in biological fluids or in pharmaceutical dosage forms, only a few spectrophotometric methods 9) based on a color reaction have been reported. Since Auerbach's description of an ion‐pair formation method for the determination of quaternary ammonium compounds 10) this method has been widely used to determine basic organic compounds by using several anionic dyes 11,12) .