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Synergistic Inhibition of Aminopeptidase B by Penicillamine or Cysteine and Metallic Salts
Author(s) -
Herranz Rosario,
GarcíaLópez M.Teresa,
Pérez Concepción
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240410
Subject(s) - penicillamine , chemistry , cysteine , zinc , aminopeptidase , amino acid , enzyme , copper , metal , stereochemistry , biochemistry , leucine , organic chemistry
The inhibition of aminopeptidase B by D‐ and L‐penicillamine and D‐ and L‐cysteine is reported. All these α‐amino‐β‐mercapto acids inhibit moderately this enzyme, with IC 50 values in the 10 −4 range. This inhibition was not reversed by Zn 2+ ions, but a synergistic effect was observed. A similar effect took place by the combined use of D‐penicillamine and Fe 2+ , Ca 2+ or Ni 2+ salts, but not with copper salts. The zinc‐D‐penicillamine and zinc‐D‐cysteine complexes 3 and 4 show an inhibitory potency approximately 5‐fold higher than that of the corresponding amino acid.