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Pyrazinderivate aus 2,3‐Pyrazindicarbonsäureanhydrid
Author(s) -
Hassan M. A.,
Zayed S. E.,
ElGaziri W. N.,
Metwally Saoud A.
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240311
Subject(s) - pyrazine , pyrimidine , chemistry , combinatorial chemistry , stereochemistry , plasmodium falciparum , malaria , organic chemistry , medicine , immunology
Pyrazine derivatives show a wide range of biological activities. Some derivatives are used for tuberculosis treatment 1) . Pyrazinosulfonamides are long acting sulfonamides 2) and in combination with certain pyrimidine derivatives have shown dramatic effects in clinical trials against resistant falciparum malaria 3) . A group of diuretics has been found among substituted amidinocarbamoyl‐aminopyrazines 4) .
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