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Induction of Drug Metabolism can be a Homeostatic Response
Author(s) -
Kourounakis Panos N.,
Rekka Eleni
Publication year - 1991
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19913240306
Subject(s) - homeostasis , drug metabolism , metabolism , drug , chemistry , pharmacology , biology , biochemistry , microbiology and biotechnology
The invasion of the body by toxic agents, in addition to the specific effects, causes a stereotype non‐specific response ‐stress‐, and an adaptive phenomenon like drug metabolism. Reserpine or hydrocortisone, causing a typical stress response, produce increased plasma concentrations of corticosterone in rats. ‐ Here it is shown that corticosterone administration once, or for three days twice daily (200 μmoles/kg) increase body resistance to zoxazolamine, methyprylon, and tetraethylammonium bromide, reduce their plasma concentrations and augment zoxazolamine, hexobarbital, and aniline in vitro drug metabolism (9000 g liver supernatant). This constitutes a good evidence that drug metabolism can be induced in response to need.