Synthesis and Calcium Antagonistic Activity of Some New 2‐Thioxo‐1,2,3,4‐tetrahydropyrimidine Derivatives | Zendy

Ertan Mevlüt | Zendy; Balkan Ayla | Zendy; Saraç Selma | Zendy; Uma Serdar | Zendy; Renaud Jean Francois | Zendy; Rollad Yves | Zendy

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Synthesis and Calcium Antagonistic Activity of Some New 2‐Thioxo‐1,2,3,4‐tetrahydropyrimidine Derivatives

Author(s) -

Ertan Mevlüt,

Balkan Ayla,

Saraç Selma,

Uma Serdar,

Renaud Jean Francois,

Rollad Yves

Publication year - 1991

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19913240302

Subject(s) - thiourea , chemistry , ethanol , ethyl acetoacetate , potency , calcium , catalysis , microsome , stereochemistry , organic chemistry , in vitro , biochemistry

A series of 1,2,3,4‐tetrahydro‐6‐methyl‐4‐(substituted phenyl)‐2‐thioxo‐5‐pyrimidinecarboxylic acid methyl esters were synthesized by condensing thiourea with methyl acetoacetate and nonsubstituted or differently substituted benzaldehydes in absol. ethanol using HCl as a catalyst according to the Biginelli reaction. The structures of the compounds were confirmed by elemental and spectroscopic analysis. ‐ The compounds were evaluated for their calcium antagonistic activity on the basis of their potency in inhibiting [ 3 H] PN 200—110 binding on microsomes obtained from rat skeletal muscle.

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