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Hydrolysis and Oxidation of 1 H ‐Benzotriazole‐carboxylic Acid Esters by Rat Liver Microsomes
Author(s) -
Jacobi Sylvia,
Hoffmann Hermann
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903231002
Subject(s) - benzotriazole , chemistry , hydrolysis , microsome , carboxylic acid , microsoma , organic chemistry , metabolism , biochemistry , stereochemistry , enzyme
The 1 H ‐benzotriazole‐carboxylic acid esters under investigation were almost ‐ with the exception of the tert .‐butylester ‐ completely hydrolyzed by rat liver microsomes. Some substrates were metabolically oxidized to a very small extent (< 1 %) yielding small amounts of possibly toxic metabolites after inhibition of the esterases with paraoxone.