Premium
Compounds with Positive Inotropic Activity, III 1 ):Synthesis of 4‐Aminoquinoline Derivatives as Potential Positive Inotropic Agents
Author(s) -
Eggert Kornelia,
Heber Dieter,
Ravens Ursula
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230911
Subject(s) - inotrope , chemistry , alkyl , biological activity , stereochemistry , side chain , structure–activity relationship , chemical synthesis , pharmacology , medicinal chemistry , biochemistry , in vitro , medicine , organic chemistry , biology , polymer
Abstract Anilinoacrylic acid derivatives 2‐4 are the key intermediates from which 1‐alkyl substituted 4‐aminoquinoline 10‐15 as well as 4‐alkylaminoquinoline derivatives 16‐23 are synthesized and examined for positive inotropic activity on isolated left atria and papillary muscles from guinea‐pig. Structure activity relationships indicate that the effect depends on the alkyl side chain of the target compounds.