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Endogenous Alkaloids in Man, VII 1 ): 1‐Trichloromethyl‐1,2,3,4‐tetrahydro‐β‐carboline ‐ A Potential Chloral‐Derived Indol Alkaloid in Man
Author(s) -
Bringmann Gerhard,
Hille Annette
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230903
Subject(s) - alkaloid , chloral , chemistry , metabolite , endogeny , stereochemistry , organic chemistry , chromatography , biochemistry
The trichloromethyl tetrahydro‐β‐carboline 5 , an imaginable, chloral‐derived mammalian indol “alkaloid”, was prepared in high yields and was shown to be formed even under mild, physiological conditions, in aqueous medium. For its detection in low concentrations, a chromatographic procedure was elaborated. Furthermore, its potential metabolite 8 was synthesized for the first time.