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Synthesis of Novel Naphtho[2,1‐b]‐1,4,5‐oxa‐ or thiadiazepines as Potential Antimicrobial and Anticancer Agents
Author(s) -
Khalil M. A.,
Habib N. S.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230806
Subject(s) - antimicrobial , chemistry , quinone , acetic acid , naphthoquinone , stereochemistry , hydrazone , chemical synthesis , combinatorial chemistry , organic chemistry , in vitro , biochemistry
Two novel series of quinone derivatives have been synthesized. Thus, condensation of 2‐ethoxycarbonylmethylthio‐; 3‐ethoxycarbonylmethylthio‐2‐methyl‐ and 3‐ethoxycarbonylmethoxy‐2‐methyl derivatives of 1,4‐naphthoquinone with substituted phenylhydrazines afforded the corresponding hydrazones, while cyclization of the same quinones with the same substituted hydrazines in glacial acetic acid gave the corresponding naphtho[2,1‐b]‐1,4,5‐oxa‐ or thiadiazepine derivatives. The antimicrobial and anticancer activities of the synthesized compounds were studied.