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The Reactions of Pindolol, Mepindolol, Carazolol, and Related Model Compounds with Triethyl Orthoformate: Pathways and Products of a New Colour Reaction
Author(s) -
Pindur Ulf,
Witzel Helmut
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230710
Subject(s) - pindolol , chemistry , triethyl orthoformate , electrophile , formate , organic chemistry , combinatorial chemistry , stereochemistry , catalysis , biochemistry , receptor
Abstract The acid‐catalysed electrophilic tandem substitutions of pindolol, mepindolol, and carazolol and some related model compounds with triethyl ortho formate give rise to new derivatives from the trishetaryl methan series. In some cases also further functionalised heterocycles were isolated. The structural aspects of the new trishetarylmethanes were discussed as C 3 ‐symmetric molecular propellers, respectively. The importance of the described reaction as colour reaction was mentioned.