Antilipidemic Agents, III: Synthesis of Some Heterocyclic Derivatives of β‐Sitosterol

Four novel series of heterocyclic derivatives of β‐sitosterol were prepared by the reaction of 3‐β‐sitosterol hemisuccinate with SOCl 2 then with thiols, amines or phenols. These series are: 3β‐[(3‐substituted‐4(3H)‐quinazolinon‐2‐yl)thiocarbonylproprionyloxy]stigmast‐5‐ene; 3β([4‐substituted‐5‐(4‐pyridyl)‐4H‐1,2,4‐triazol‐3‐yl]thiocarbonylpropionyloxy}stigmast‐5‐ene; 3β‐[(5‐substituted‐1,3,4‐thiadiazol‐2‐yl)carbamoylpropionyloxy]stigmast‐5‐ene and 3β‐substituted carbanoyl or oxycarbonylpropionyloxy)stigmast‐5‐ene. The antilipidemic activity of representative compounds was studied.