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Synthesis and Structure‐Activity Relationship of Some New β‐Blocking Agents with Possible α‐Adrenoreceptor Activity
Author(s) -
Bergmann JáNos,
Takács KáLmáN
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230703
Subject(s) - chemistry , guanidine , blocking (statistics) , structure–activity relationship , stereochemistry , receptor , intrinsic activity , combinatorial chemistry , biophysics , pharmacology , biochemistry , in vitro , agonist , biology , statistics , mathematics
A series of new phenoxypropanolamines with cyclic guanidine and isothiourea moieties has been prepared and investigated for non‐specific α‐ and α‐adrenoreceptor activity by receptor binding experiments on crude rat brain membrane. Some of them [ 9a, 10c ] possess affinity for both β‐ and α‐adrenoreceptors.