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Synthesis of Vinca Alkaloids and Related Compounds, XLIV 1) : Synthesis of Trifluoro‐apovincaminic Acid Ester
Author(s) -
Incze Märia,
Sóti Ferenc,
KardosBalogh Zsuzsanna,
KajtárPeredy MÁRia,
Szántay Csaba
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230604
Subject(s) - vinca , chemistry , iminium , derivative (finance) , alkaloid , ethyl ester , salt (chemistry) , stereochemistry , organic chemistry , pharmacology , biology , ion , financial economics , economics
Via the intermediate iminium salt 8 the 21,21,21‐trifluoro‐apovincaminic acid ethyl ester ( 2 ), a derivative of CAVINTON R ( 1 ) was synthesized. The pharmacological effect of 2 changed dramatically compared with the parent compound.