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Non‐Steroidal Antiinflammatory Agents, II 1) : Synthesis of Novel Pyrazole and Pyrazoline Derivatives of 4(3H)‐Quinazolinone Nicht‐steroidale Antiphlogistika, 2. Mitt. 1) : Synthese neuer Pyrazol‐ und Pyrazolin‐Derivate des 4(3H)‐Chinazolinons
Author(s) -
Farghaly A. M.,
Chaaban I.,
Khalil M. A.,
Behkit A. A.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230511
Subject(s) - quinazolinone , chemistry , citation , stereochemistry , computer science , world wide web
Antiinflammatory and/or analgesic activities have been ascribed to compounds containing the 4(3H)-quinazolinone or pyrazole moiety. Continuation to the previous work in the field of the synthesis of non-steroidal antiinflammatory 4(3H)-quinazolinones, the present investigation deals with the synthesis of new compounds having the pyrazole or pyrazoline and 4(3H)-quinazolinone moieties in one molecule, hoping that such combination might improve their antiinflammatory activity. alpha,beta-unsaturated ketones when treated with hydrazine hydrate achieve cyclization to the corresponding pyrazoline derivatives, whereas, when arylhydrazines are used, pyrazole derivatives are formed.