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Synthesis of Novel 2‐Substituted Quinoline Derivatives: Antimicrobial, Inotropic, and Chronotropic Activities
Author(s) -
Farghaly A. M.,
Habib N. S.,
Khalil M. A.,
ElSayed O. A.,
Bistawroos A. E.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230414
Subject(s) - chronotropic , quinoline , antimicrobial , chemistry , inotrope , methylene , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry , medicine , heart rate , blood pressure
Three novel series of quinoline derivatives have been prepared by cyclization of the intermediate 3‐(13‐dioxolan‐2‐yl)‐2‐substituted thiocarbamoyl‐hydrazinoquinolines with different α‐halocarbonyl compounds. These series are: 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐4‐phenylthiazolin‐2‐ylidene)hy‐drazinoquinolines; 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐5‐ethoxycarbonyl‐4‐methylthiazoline‐2‐ylidene)hydrazinoquinolines and 3‐(1,3‐dioxolan‐2‐yl)‐2‐(3‐substituted‐4‐thiazolidinon‐2‐yl)hydrazinoquinolines. The active methylene group of the latter series was used for the preparation of their arylidene derivatives. The antimicrobial as well as inotropic and chronotropic activities of the prepared compounds were studied.