Adrenergic Agents, II 1) : 1‐Aryl‐N 2 ‐alkyl‐ethanediamines as Isosters of Adrenergic Arylethanolamines

A family of 1‐aryl‐N 2 ‐alkyl‐ethanediamines 1 isosteric with the N‐alkyl‐arylethanolamines are described. Although the prepared compounds were generally less potent than the N‐alkyl‐arylethanolamines, the 1‐aryl‐N'‐(phenylmethyl)‐N‐alkyl‐1,2‐ethanediamines derivatives 6 , are more active than the debenzylated free amino analogs 1 , which may be indicative of the importance of the lipophilicity of the substituent at the alpha position to the aromatic ring.