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Adrenergic Agents, II 1) : 1‐Aryl‐N 2 ‐alkyl‐ethanediamines as Isosters of Adrenergic Arylethanolamines
Author(s) -
Berger Sarah,
Nudelman Abraham
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230410
Subject(s) - alkyl , lipophilicity , chemistry , substituent , aryl , stereochemistry , medicinal chemistry , ring (chemistry) , adrenergic , organic chemistry , biochemistry , receptor
A family of 1‐aryl‐N 2 ‐alkyl‐ethanediamines 1 isosteric with the N‐alkyl‐arylethanolamines are described. Although the prepared compounds were generally less potent than the N‐alkyl‐arylethanolamines, the 1‐aryl‐N'‐(phenylmethyl)‐N‐alkyl‐1,2‐ethanediamines derivatives 6 , are more active than the debenzylated free amino analogs 1 , which may be indicative of the importance of the lipophilicity of the substituent at the alpha position to the aromatic ring.