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Antimicrobial Activity of Basic Cholane Derivatives Part IX
Author(s) -
Bellini A. M.,
Mencini E.,
Quaglio M. P.,
Guarneri M.,
Fini A.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230404
Subject(s) - antimicrobial , chemistry , bacteria , pseudomonas aeruginosa , yeast , pseudomonas , stereochemistry , deoxycholic acid , combinatorial chemistry , biochemistry , organic chemistry , biology , bile acid , genetics
Twenty new compounds derived from deoxycholic acid have been synthesized. They contain two basic functions: at C‐24 (benzylamino, morpholino, diethanolamino, N,N‐diethylethylenediamino, N‐methylpiperazino) and at β‐C‐3 (amino, methylamino, ethylamino, benzylamino). The compounds showed interesting antimicrobial activity, as expressed in terms of the low M.I.C. values (0.9‐31‐μ/ml) against five Gram (+) and four Gram (−) strains, two fungi and one yeast. The compounds inhibit the production of a fluorescent pigment in Pseudomonas aeruginosa : this result suggests that the ability to cross the bacterium cell membrane is the first step of activity. A discussion in terms of structure‐activity relationship is reported.