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Synthesis and Antimicrobial Evaluation of Some Arylhydrazones of 4‐[(2‐Methylimidazo[1,2‐a]pyridine‐3‐yl)azo]benzoic Acid Hydrazide
Author(s) -
Cesur Zafer,
Büyüktimkin Servet,
Büyüktimkin Nadir,
Derbentli Sengül
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230304
Subject(s) - hydrazide , chemistry , antimicrobial , pyridine , benzoic acid , klebsiella pneumoniae , escherichia coli , organic chemistry , stereochemistry , medicinal chemistry , biochemistry , gene
Abstract A short series of arylhydrazones of 4‐[(2‐methylimidazo[1,2‐a]pyridine‐3‐yl)azo]benzoic acid hydrazide was synthesized and tested for antimicrobial activity. All of the compounds show antimicrobial activity against Escherichia coli . A few members were also active against Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa . The interplanar angle (θ) between the aryl ring and the adjacent azomethine group of some representative compounds was measured by electronic absorption spectroscopy. No structure‐activity‐relationship between interplanar angle or lipophily and activity was found.