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Lipophilicity of Some Substituted Morpholine Derivatives Synthesized as Potential Antinociceptive Agents
Author(s) -
Rekka Eleni,
Retsas Stavros,
Demopoulos Vassilis J.,
Kourounakis Panos N.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230114
Subject(s) - lipophilicity , morpholine , chemistry , piperidine , alkoxy group , analgesic , stereochemistry , combinatorial chemistry , organic chemistry , pharmacology , alkyl , medicine
Some substituted 2‐alkoxy‐morpholines have been synthesized as potential antinociceptive agents. These compounds share some structural characteristics of the piperidine analgesics. Their lipophilicity, expressed as log P (octanol‐water) and as R M values (from reversed phase thin layer chromatography) was determined. Correlation of these two lipophilicity parameters indicated the classification of the tested compounds into two subgroups. Acute toxicity and, for some selected structures, analgesic activity are reported.