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An Opioid Agonist with Preference for κ‐Opioid Receptors: (−)‐N‐Cyclopropylmethylmorphinan‐6‐one
Author(s) -
Schmidhammer Helmut,
Trenker Ellen,
Burkard Willy P.,
EggsteinAeppli Lislott,
Hefti Fridolin,
Holck Mark I.
Publication year - 1990
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19903230108
Subject(s) - opioid , agonist , pharmacology , chemistry , receptor , opioid receptor , opioid peptide , stereochemistry , medicine , biochemistry
N‐Cyclopropylmethyl‐ and N‐cyclobutylmethylmorphinan‐6‐one ( 3 and 4 , respectively) were prepared from N‐methylmorphinan‐6‐one ( 1 ). The pharmacological studies showed 3 and 4 to be potent opioid agonists. Compound 3 was found to have preference for κ rather than μ opioid receptors.
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