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Investigations on the Antiproliferative Effects of Amino Acid Antagonists Targeting for Aminoacyl‐tRNA Synthetases Part II ‐ The Antileukemic Effect
Author(s) -
Laske Reiner,
Schönenberger Helmut,
Holler Eggehard
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893221205
Subject(s) - aminoacyl trna synthetase , amino acid , cell culture , biochemistry , chemistry , growth inhibition , transfer rna , inhibitory postsynaptic potential , cell growth , leukemia , biology , pharmacology , stereochemistry , rna , genetics , gene , neuroscience
Amino acid antagonists with proven or potential inhibitory activities on aminoacyl‐tRNA synthetases were tested for their antiproliferative effect against the murine leukemic cell line P388D 1 . Micromolar concentrations of the compounds S‐tritylcysteine ( 18 ), fenitropan and ß‐chloroalanine gave strong growth inhibition. In the mouse only 18 was effective against leukemia P388 (T/C=211%). The inhibitory effect on aminoacyl‐tRNA synthetases and the antiproliferative action on P388D 1 or P388 could not be correlated.