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Spectral and Chemical Properties of Pyrazino‐[2,1‐a]‐isoquinolin‐4‐one Derivatives
Author(s) -
Kiec'Koowicz Katarzyna
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893221104
Subject(s) - chemistry , dehydrogenation , spectral properties , derivative (finance) , spectral analysis , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , spectroscopy , catalysis , physics , quantum mechanics , financial economics , economics
Spectral properties of some acyl derivatives of pyrazino‐[2,1‐a]‐isoquinolin‐4‐one are described using modern pulse sequences. The dehydrogenation of 2‐(cyclohexylcarbonyl)‐1,2,3,6,7,11b‐hexahydro‐4 H ‐pyrazino‐[2,1‐a]‐isoquinolin‐4‐one ( 2 ) with sulphur gave the 1,11b dehydro derivative 6 . Oxidation with MCPBA of the pyridyl derivative 5 yielded the N‐oxide 8 , while from 2 and 6 the same product was obtained, the structure of which was assigned as 2‐[2‐N‐(cyclohexylcarbonyl)‐N‐formyl‐aminoacyl]‐1,2,3,4‐tetrahydro‐isoquinolin‐1‐one ( 9 ) on the basis of spectral data.