Spectral and Chemical Properties of Pyrazino‐[2,1‐a]‐isoquinolin‐4‐one Derivatives | Zendy

Kiec'Koowicz Katarzyna | Zendy

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Spectral and Chemical Properties of Pyrazino‐[2,1‐a]‐isoquinolin‐4‐one Derivatives

Author(s) -

Kiec'Koowicz Katarzyna

Publication year - 1989

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19893221104

Subject(s) - chemistry , dehydrogenation , spectral properties , derivative (finance) , spectral analysis , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , spectroscopy , catalysis , physics , quantum mechanics , financial economics , economics

Spectral properties of some acyl derivatives of pyrazino‐[2,1‐a]‐isoquinolin‐4‐one are described using modern pulse sequences. The dehydrogenation of 2‐(cyclohexylcarbonyl)‐1,2,3,6,7,11b‐hexahydro‐4 H ‐pyrazino‐[2,1‐a]‐isoquinolin‐4‐one ( 2 ) with sulphur gave the 1,11b dehydro derivative 6 . Oxidation with MCPBA of the pyridyl derivative 5 yielded the N‐oxide 8 , while from 2 and 6 the same product was obtained, the structure of which was assigned as 2‐[2‐N‐(cyclohexylcarbonyl)‐N‐formyl‐aminoacyl]‐1,2,3,4‐tetrahydro‐isoquinolin‐1‐one ( 9 ) on the basis of spectral data.

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