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Synthesis of 4‐Azido‐N‐[2‐(diethylmethylammonium)ethyl]benzamide Iodide: A Photolabile Derivative of Procainamidethobromide
Author(s) -
Mol Wim E. M.,
Müller Michael,
Kurz Gerhart,
Meijer Dirk K. F.
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893221009
Subject(s) - benzamide , chemistry , ethyl iodide , derivative (finance) , iodide , photodissociation , methyl iodide , kinetics , stereochemistry , medicinal chemistry , photochemistry , organic chemistry , physics , quantum mechanics , financial economics , economics
In order to identify polypeptides interacting with organic cations like PAEB the photolabile derivative 4‐azido‐N‐[2‐diethyl([ 3 H]methyl)ethyl]benzamide iodide with a specific radioactivity of 4.3 Ci/mmol was synthesized. Photolysis of this derivative using a Rayonet RPR 100 reactor with a maximum emission at 300 nm obeyed first order kinetics with t 1/2 = 13.5 min. The photochemical properties of this azido‐derivative of PAEB indicate that it may be well suited for the identification of binding polypeptides by photoaffinity labeling studies.