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Studies on Amino‐Azoles: Synthesis of 3‐Methylaminopyrazole Derivatives
Author(s) -
Ramiz Mahmoud M. M.,
Elghandour Ahmed H. H.,
Ibrahim Mohamed K. A.,
Mansour Omar A. E.R.
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220909
Subject(s) - chemistry , reagent , methylene , combinatorial chemistry , organic chemistry , chemical synthesis , in vitro , biochemistry
Diazotized 3 coupled with active methylene reagents to afford compounds 5 and 10 . Aromatic diazonium salts coupled with 3 to afford 12 , which was converted into 3 in refluxing AcOH/H 2 SO 4 . The reaction of 3 with isothiocyanates resulted in the formation of compounds 14 , 15 , and 16 .