10‐(ω‐Carboxyacyl)‐dithranol‐Derivatives | Zendy

Tanzer Helene | Zendy; Seidel Matthias | Zendy; Wiegrebe Wolfgang | Zendy

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10‐(ω‐Carboxyacyl)‐dithranol‐Derivatives

Author(s) -

Tanzer Helene,

Seidel Matthias,

Wiegrebe Wolfgang

Publication year - 1989

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19893220712

Subject(s) - dithranol , chemistry , succinic acid , dicarboxylic acid , hydrolysis , organic chemistry , phosphate , dermatology , medicine , psoriasis

The title compounds are not available by hydrolysis of the pertinent esters on a preparative scale. Therefore, they were prepared by base catalyzed condensation of dicarboxylic acid dichlorides or succinic acid monobenzylesterchloride, respectively, with dithranol ( 1 ). Their IC 50 ‐values for glucose‐6‐phosphate dehydrogenase are lower than that of dithranol ( 1 ), whilst 10‐ethyldithranol ( 6 ) and the o‐(ω‐carboxyalkyl)‐derivatives 8 and 9 are weaker inhibitors.

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