Premium
10‐(ω‐Carboxyacyl)‐dithranol‐Derivatives
Author(s) -
Tanzer Helene,
Seidel Matthias,
Wiegrebe Wolfgang
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220712
Subject(s) - dithranol , chemistry , succinic acid , dicarboxylic acid , hydrolysis , organic chemistry , phosphate , dermatology , medicine , psoriasis
The title compounds are not available by hydrolysis of the pertinent esters on a preparative scale. Therefore, they were prepared by base catalyzed condensation of dicarboxylic acid dichlorides or succinic acid monobenzylesterchloride, respectively, with dithranol ( 1 ). Their IC 50 ‐values for glucose‐6‐phosphate dehydrogenase are lower than that of dithranol ( 1 ), whilst 10‐ethyldithranol ( 6 ) and the o‐(ω‐carboxyalkyl)‐derivatives 8 and 9 are weaker inhibitors.