Electron Impact Induced Loss of C‐5/C‐8 Substituents of 1,2,3,4‐Tetrahydroisoquinolines, V: Synthesis and Mass Spectrometric Fragmentation of Dihydroisoindole Derivatives | Zendy

Knefeli Frank | Zendy; Mayer Klaus K. | Zendy; Wiegrebe Wolfgang | Zendy

Premium

Electron Impact Induced Loss of C‐5/C‐8 Substituents of 1,2,3,4‐Tetrahydroisoquinolines, V: Synthesis and Mass Spectrometric Fragmentation of Dihydroisoindole Derivatives

Author(s) -

Knefeli Frank,

Mayer Klaus K.,

Wiegrebe Wolfgang

Publication year - 1989

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19893220708

Subject(s) - chemistry , electron ionization , fragmentation (computing) , substituent , mass spectrum , ion , mass spectrometry , medicinal chemistry , stereochemistry , organic chemistry , chromatography , ionization , computer science , operating system

C‐8‐substituted N‐methyl‐1,2,3,4‐tetrahydroisoquinoline radical cations lose the complete substituent in a one step reaction giving rise to an unexpected ion at m/z 146, which is probably identical with the dihydroisoindolyl‐methyl‐cation A . The dihydroisoindoles 1 , 10 , and 16 were prepared as potentially alternative precursors of ion A . However, the ion at m/z 146 in their El mass spectra is of very low intensity, so CID‐experiments for structural comparison could not be performed. The electron impact induced fragmentations of 1 , 10 , and 16 are discussed.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research