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Researches on Antibacterial and Antifungal Agents, X. Synthesis and Antifungal Activities of 1‐{p‐Methyl‐α‐[4‐(1H‐pyrrol‐1‐yl)phenyl]benzyl}azoles and Some Related Products
Author(s) -
Massa Silvio,
Stefancich Giorgio,
Corelli Federico,
Silvestri Romano,
Mai Antonello,
Artico Marco,
Panico Salvatore,
Simonetti Nicola
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220609
Subject(s) - bifonazole , miconazole , ketoconazole , chemistry , moiety , imidazole , azole , candida albicans , antifungal , stereochemistry , antimicrobial , chemical synthesis , pyrrole , organic chemistry , in vitro , microbiology and biotechnology , biochemistry , biology
The synthesis and antifungal activities against Candida albicans and Candida spp. of some pyrrole analogues of bifonazole are reported. 1‐{p‐Methyl‐α‐[4‐(1H‐pyrrol‐1‐yl)phenyl]benzyl}imidazole was found to be equipotent or sometimes superior to bifonazole and ketoconazole, and lightly inferior to miconazole. Substitution of the imidazole moiety with other azoles retained some activities. No activity was shown when the azole aromatic rings were replaced by the heteroalicyclic ones.