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Phenanthrylalkanoic Acids, III: Syntheses and Biological Activities of 4‐Phenanthryl Derivatives
Author(s) -
Eirín Ana,
Fernández Franco,
Gómez Generosa,
López Carmen,
Santos Ana,
Calleja José M.,
Cano Ernesto
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220508
Subject(s) - saponification , chemistry , ethyl bromoacetate , analgesic , propanoic acid , propionates , aromatization , stereochemistry , medicinal chemistry , yield (engineering) , organic chemistry , pharmacology , biology , materials science , metallurgy , catalysis
Reformatsky reactions between 2,3‐dihydro‐4(1 H )‐phenanthrenone ( 5 ) and ethyl α‐bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4‐phenanthrylacetic ( 1 ) and 2‐(4‐phenanthryl)propanoic ( 2 ) acids. The analgesic and antiinflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.