Phenanthrylalkanoic Acids, III: Syntheses and Biological Activities of 4‐Phenanthryl Derivatives | Zendy

Eirín Ana | Zendy; Fernández Franco | Zendy; Gómez Generosa | Zendy; López Carmen | Zendy; Santos Ana | Zendy; Calleja José M. | Zendy; Cano Ernesto | Zendy

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Phenanthrylalkanoic Acids, III: Syntheses and Biological Activities of 4‐Phenanthryl Derivatives

Author(s) -

Eirín Ana,

Fernández Franco,

Gómez Generosa,

López Carmen,

Santos Ana,

Calleja José M.,

Cano Ernesto

Publication year - 1989

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19893220508

Subject(s) - saponification , chemistry , ethyl bromoacetate , analgesic , propanoic acid , propionates , aromatization , stereochemistry , medicinal chemistry , yield (engineering) , organic chemistry , pharmacology , biology , materials science , metallurgy , catalysis

Reformatsky reactions between 2,3‐dihydro‐4(1 H )‐phenanthrenone ( 5 ) and ethyl α‐bromoacetate or propanoate yield several unsaturated esters which, upon aromatization followed by saponification, lead to the 4‐phenanthrylacetic ( 1 ) and 2‐(4‐phenanthryl)propanoic ( 2 ) acids. The analgesic and antiinflammatory properties of 1 and 2 were measured and compared with those of Fenbufen.

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