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Competitive Reactions in the Synthesis of Nitrendipine
Author(s) -
Raev Lyubomir D.,
Ivanov Ivo C.
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220503
Subject(s) - chemistry , nitrendipine , knoevenagel condensation , ammonia , chemical synthesis , organic chemistry , stereochemistry , combinatorial chemistry , catalysis , biochemistry , calcium , in vitro
In the synthesis of nitrendipine ( 4ab ) according to methods A and B the corresponding symmetrical diesters 4aa and 4bb have been found as byproducts. The formation of the substituted 1,2,3,4‐tetrahydropyrimidines 6a and b via retrograde Knoevenagel reaction has been proved in method B. The preparation of 6a , b was achieved by reaction of 3‐nitrobenzylideneacetoacetates 5a , b with ammonia.