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Quinazolinones, 13.Comm. Synthesis of 3‐[2‐(2,3‐Dihydro‐5‐phenyl‐4‐substituted‐3H‐1,2,4‐triazole‐3‐thione‐2‐yl)‐acetylamino]‐2‐methyl‐4(3H)‐quinazolinones and their pharmacological activities
Author(s) -
Büyüktimkin Servet,
Büyüktimkin Nadir,
Özdemir Osman,
Rollas Sevim
Publication year - 1989
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19893220112
Subject(s) - chemistry , 1,2,4 triazole , triazole , stereochemistry , bicyclic molecule , 1,2,3 triazole , combinatorial chemistry , medicinal chemistry , organic chemistry
Some 2‐methyl‐3‐triazole‐substituted‐4(3H)‐quinazolinones 3a – f were prepared and tested for their H 1 ‐ and H 2 ‐ antihistaminic activities. In addition these compounds are central nervous system depressants and anticonvulsants. 3e shows highly significant decrease of locomotor activity.