Quinazolinones, 13.Comm. Synthesis of 3‐[2‐(2,3‐Dihydro‐5‐phenyl‐4‐substituted‐3H‐1,2,4‐triazole‐3‐thione‐2‐yl)‐acetylamino]‐2‐methyl‐4(3H)‐quinazolinones and their pharmacological activities | Zendy

Büyüktimkin Servet | Zendy; Büyüktimkin Nadir | Zendy; Özdemir Osman | Zendy; Rollas Sevim | Zendy

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Quinazolinones, 13.Comm. Synthesis of 3‐[2‐(2,3‐Dihydro‐5‐phenyl‐4‐substituted‐3H‐1,2,4‐triazole‐3‐thione‐2‐yl)‐acetylamino]‐2‐methyl‐4(3H)‐quinazolinones and their pharmacological activities

Author(s) -

Büyüktimkin Servet,

Büyüktimkin Nadir,

Özdemir Osman,

Rollas Sevim

Publication year - 1989

Publication title -

archiv der pharmazie

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.468

H-Index - 61

eISSN - 1521-4184

pISSN - 0365-6233

DOI - 10.1002/ardp.19893220112

Subject(s) - chemistry , 1,2,4 triazole , triazole , stereochemistry , bicyclic molecule , 1,2,3 triazole , combinatorial chemistry , medicinal chemistry , organic chemistry

Some 2‐methyl‐3‐triazole‐substituted‐4(3H)‐quinazolinones 3a – f were prepared and tested for their H 1 ‐ and H 2 ‐ antihistaminic activities. In addition these compounds are central nervous system depressants and anticonvulsants. 3e shows highly significant decrease of locomotor activity.

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