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Indoles, VII 4,9‐Dihydropyrano[3,4‐b]indol‐1(3H)‐ones from meta‐substituted α‐Phenylhydrazono‐δ‐lactones ‐ Synthesis and Regioselectivity
Author(s) -
Lehmann Jochen,
Pohl Ursula
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883211211
Subject(s) - regioselectivity , steric effects , chemistry , stereochemistry , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis
The indolization of 3a‐f , available by reaction of 1 with the diazonium salts 2a‐f , produces mixtures of position isomers. Significant influences on the ratio 4/5 by electronic of steric effects of the chosen substituents cannot be recognized. Indolization of 6 also gives a mixture ‐ 10 and 11 ‐,on the other hand 9 yields pure 12 .
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