Premium
Synthesis of Some Substituted Carbamodithioic Acid Esters and Their Anticholinergic Properties
Author(s) -
Safak Cihat,
Erdoǧan Hakkl,
Ertan Mevlüt,
Sunal Rümeysa
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883211207
Subject(s) - dithiocarbamate , antispasmodic , chemistry , anticholinergic , piperazine , ileum , parasympatholytics , anticholinergic agents , biological activity , stereochemistry , medicinal chemistry , organic chemistry , pharmacology , biochemistry , in vitro , medicine
Eight new dithiocarbamates have been prepared by the reaction of 5‐chloro‐3‐methyl‐6‐(2‐bromopropionyl)‐2‐benzoxazolinone and substituted potasium dithiocarbamate derivatives. Their structures have been elucidated by UV‐, IR‐, and NMR‐spectra and by elemantary analysis. The title compounds have been assayed for their antispasmodic activity on guineapig ileum, they possess spezific anticholinergic properties.