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Flow Injection Amperometric Determination of Pharmaceuticals
Author(s) -
González F.,
Tarin P.,
Maspoch S.,
Blanco M.
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883211005
Subject(s) - amperometry , chemistry , nicardipine , analyte , chromatography , flow injection analysis , piperazine , linear range , electrode , detection limit , electrolyte , adsorption , analytical chemistry (journal) , electrochemistry , organic chemistry , calcium
A new method is proposed for the flow injection determination of nicardipine and OPAP, [N‐(2‐oxo‐1‐pyrrolidinyl)‐acetyl]‐N′‐(3‐phenylprop‐2‐en‐2‐yl)piperazine, with amperometric detection at a fixed potential by oxidation on a glassy carbon electrode. The influence of the injected volume, flow rate, pH and electrolyte composition on the sensitivity is studied. In the proposed method, the effect of the analyte adsorption on the electrode surface is overcome. The response is linear over the range 0.3–50 mg/L for OPAP and 0.2–16 mg/L for nicardipine, their respective detection limits being 0.1 and 0.05 mg/L.