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Synthesis and Antihypertensive Activity of Some Aminoguanidine and Amidrazone Derivatives
Author(s) -
Vio Luciano,
Mamolo Maria Grazia,
Pellizer Giorgio
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883211002
Subject(s) - guanabenz , chemistry , antihypertensive drug , pharmacology , stereochemistry , biochemistry , medicine , blood pressure , receptor , agonist
The synthesis of some benzylidenaminoguanidine, amidrazone and 1,2,4‐triazole derivatives has been described. The antihypertensive activity of these compounds has been evaluated on spontaneously hypertensive rats. The activity of the aminoguanidine derivatives was somewhat less pronounced than that of the reference drug guanabenz. Amidrazone derivatives showed remarkable antihypertensive properties, whereas the activity of the correspondent 1,2,4‐triazole derivatives was of minor interest.