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Nitrile als Synthesebausteine: Polyfunktionalisierte Azabiaryle
Author(s) -
Ibrahim Nadia S.,
Mohamed Mona H.,
Elnagdi Mohamed H.
Publication year - 1988
Publication title -
archiv der pharmazie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.468
H-Index - 61
eISSN - 1521-4184
pISSN - 0365-6233
DOI - 10.1002/ardp.19883210919
Subject(s) - bifunctional , chemistry , reagent , reactivity (psychology) , nucleophile , organic chemistry , combinatorial chemistry , organic synthesis , nitrile , catalysis , medicine , alternative medicine , pathology
In previous work we have shown that the reaction of trichloroacetonitrile with bifunctional nitriles leads to aminoheterocycles having a trichloromethylsubstituent. The trichloromethyl function in these heteroaromatic amines can be readily replaced by nucleophilic reagents. Recent interest in utility of this synthetic approach for preparation of aromatic aminoheterocycles 2–4) as well as reported abnormal reactivity of the trichloromethyl function in π‐deficient heterocycles prompt us to report our further results in this area. This work was undertaken in connection with a biological chemistry project in our laboratories when samples of different derivatives of azabiaryls were required.